The wrinklers act multiplicatively, so ideally you want to have a full set of 10 (or 12, or 14, depending on your heavenly upgrades and auras) for most of the time you have them.
When To Pop Wrinklers
The wrinklers act multiplicatively, so ideally you want to have a full set of 10 (or 12, or 14, depending on your heavenly upgrades and...